True Facts: The Self-Sacrificing Amoeba

August 4, 2022 by 43 Comments

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The family of Dr John Bonner, Princeton University

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UMass Amherst Libraries

Bianchi, E., Doe, B., Goulding, D. et al. Juno is the egg Izumo receptor and is essential for mammalian fertilization. Nature 508, 483–487 (2014).

Bloomfield G, Paschke P, Okamoto M, Stevens TJ, Urushihara H. Triparental inheritance in Dictyostelium. Proc Natl Acad Sci U S A. 2019 Feb 5;116(6):2187-2192. doi: 10.1073/pnas.1814425116. Epub 2019 Jan 22. Erratum in: Proc Natl Acad Sci U S A. 2019 Feb 25;: PMID: 30670662; PMCID: PMC6369745.

Bonner, J.. (2008). The social amoebae: The biology of cellular slime molds. The Social Amoebae: The Biology of Cellular Slime Molds.

Dormann D, Weijer CJ. Imaging of cell migration. EMBO J. 2006 Aug 9;25(15):3480-93. doi: 10.1038/sj.emboj.7601227. PMID: 16900100; PMCID: PMC1538568.

Kurato Mohri, Ryodai Tanaka, Seido Nagano, Live cell imaging of cell movement and transdifferentiation during regeneration of an amputated multicellular body of the social amoeba Dictyostelium discoideum, Developmental Biology, Volume 457, Issue 1, 2020, Pages 140-149, ISSN 0012-1606,

Kuwana S, Senoo H, Sawai S, Fukuzawa M. A novel, lineage-primed prestalk cell subtype involved in the morphogenesis of D. discoideum. Dev Biol. 2016 Aug 15;416(2):286-99. doi: 10.1016/j.ydbio.2016.06.032. Epub 2016 Jun 29. PMID: 27373689.

Mori M, Yao T, Mishina T, Endoh H, Tanaka M, Yonezawa N, Shimamoto Y, Yonemura S, Yamagata K, Kitajima TS, Ikawa M. RanGTP and the actin cytoskeleton keep paternal and maternal chromosomes apart during fertilization. J Cell Biol. 2021 Oct 4;220(10):e202012001. doi: 10.1083/jcb.202012001. Epub 2021 Aug 23. PMID: 34424312; PMCID: PMC8404465.

Orvieto, Raoul & Shimon, Chen & Rienstein, Shlomit & Jonish-Grossman, Anat & Shani, Hagit & Aizer, Adva. (2020). Do human embryos have the ability of self- correction?. Reproductive Biology and Endocrinology. 18. 10.1186/s12958-020-00650-8.

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Raper, Kenneth B., and Dorothy I. Fennell. β€œStalk Formation in Dictyostelium.” Bulletin of the Torrey Botanical Club 79, no. 1 (1952): 25–51.

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43 Replies to “True Facts: The Self-Sacrificing Amoeba”

  1. U & A says:

    What I learned from this:

    When life says you're weak and disposable and, Tag! you're it! You get to be just a stalk. You give them the finger.

    Did I get that right? πŸ˜‚πŸ€£πŸ˜‚πŸ€£

  2. Captain Jack says:

    I wish Zefrank was my high school science 🧬 teacher. I might have aced ♠️every exam 😁

  3. Sentient Ejaculate!!!πŸ€£πŸ˜‚πŸ€£πŸ˜‚ Yeah that was the one…

  4. PoyntFury says:

    "This is a bizarre story about sex, sacrifice, cannibals… there's even a parade!"

    Careful. You'll draw conspiracy nuts with talk like that.

  5. Mr. Joshua says:

    I always learn a lot from these videos

  6. "And then it does some normal shit."
    "Just kidding."

    I can't believe I fell for this, this is a ZeFrank video, nothing is normal shit.

  7. D Shepherd says:

    πŸ€—πŸ€—πŸ€—πŸ€— This retired research biologist (early from a health issue) πŸ’“ your channel. You are a brilliant albeit brief, spot of light, learning, & laughter, during some rather dark times for us all.

    Never before have I equated slime molds with, β€œThe Borg.” I salute you good sir! 😁

  8. How am I supposed to go back to work after watching this? FUCKING WILD.

  9. True fact: I searched YouTube for "nature documentary guy who says bebbes" to find this video.

  10. Tskmaster says:

    As per usual, nature continues to fascinate, horrify, entertain, baffle, disgust, befuddle and be a part of me.

  11. Satriyo Aji says:

    Ugh, eating pizza boy, after fulfilling your carnal desire.
    Just wow

  12. Absolutely awesome πŸ‡¨πŸ‡¦πŸŒžπŸπŸ˜

  13. In all the years of YouTube, I've subscribed to only 5 channels. Ze is one. I don't know how to give Ze a better compliment. You ROCK, Sir!

  14. Personal preference says "Go for the stuffed delivery girl."

  15. John L Rice says:

    At about 2:40 to 2:45 . . . I suddenly laughed so loud I startled myself! 🀣🀣🀣🀣🀣🀣🀣🀣🀣🀣🀣🀣

  16. Mark G says:

    This was excellent, I actually learned stuff from your Channel

  17. Zed Kay says:

    This channel makes me want to get rid of life forms.

  18. This was super educational! It really kinda shows ya how complex life on earth and beyond could form together from less complicated life.

  19. Daniel Shae says:

    Thought it said Disco Elysium

  20. nacoran says:

    And now I want pizza.

    What is wrong with me? (Good place near the corner of 20 and 155).

  21. lr 21 says:

    Bwahahahaha 🀣

  22. Dip his toes in it

  23. I have to say, this one was a bit more chaotic and risque than I was expecting. Don't stop, it was hilarious.

  24. Ferria says:

    I enjoyed sceince in school however I would have truly enjoyed it more if my teachers were like you.❀

  25. fuxrox says:

    Sentient Ejaculate 🀣🀣🀣

  26. New Message says:

    That's how the goo do.

  27. Giovanni says:

    What. The fuck.

  28. Charming as usual, Zefrank. 🀌

  29. Those little dickies are impressive! So about that stuffed crust pizza… 😘 That was fantastic as always!! Learning with you is too much fun. I love you 😍🧑πŸ₯°πŸ˜˜

  30. Specter Owl says:

    Never been so excited about a moving sneezes that look like condoms

  31. AllFiery says:

    I had amoebiasis when I was little and it was one of the most excruciating experience in my life.

  32. Oh what a delight to spot a new True Facts. LOVE your stuff. Still wondering though if Jerry is real or just another personality. lol. Keep these going. Love it.

  33. Human beings the size of amoebas. Here, get that down your esophagus Jumbo! πŸ‡¬πŸ‡§TYO. How long have I waited for an opportunity to deploy that one!

  34. Adam says:

    Last time I heard about amoebas was about 10 years ago in grade 10 science. I certainly learned more now than I did then

  35. Romalac says:

    I wonder if a mechanism like this is basically how multicellular organisms first developed. It certainly seems like a good start to get such a system going, and seems to have a lot of parallels to how our own tissues do things.

  36. Casey Kahler says:

    This was an absolute mind blow. This was a crazy episode. Thank you Zefrank

  37. Another perfect video

  38. I love how with even more complicated topics like this, Zefrank still makes it funny and understandable.